成年患者的乳病表现和随访的性别相关差异
Roberta Elisa Rossi1,2, Benedetta Masoni1,2, Diletta De Deo1,2
1Gastroenterology and Endoscopy Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Expert review of gastroenterology & hepatology
|July 19, 2025
概括
在乳病 (CD) 呈现方面存在性别差异,但很小,并且经常通过无质饮食 (GFD) 得到解决. 对GFD的饮食坚持表明,成人CD患者没有显著的基于性别的差异.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 病 (CD) 呈现出已知的女性占主导地位 (2-2.5:1比).
- 之前关于CD呈现和结果的性别差异的研究产生了相互矛盾的结果.
研究的目的:
- 在诊断时调查CD的性别特异性临床表现.
- 评估坚持无质饮食 (GFD) 的性别差异.
- 为了评估临床症状的修改与GFD坚持成年CD患者.
主要方法:
- 在2022年9月至2024年7月期间,对191名成年乳病患者 (141名女性,50名男性) 进行了回顾性分析.
- 性别之间的临床表现,肠外表现和遵守GFD的比较.
- 统计分析以确定疾病特征和GFD遵守的性别差异.
主要成果:
- 虽然胃肠道症状在女性 (59%) 和男性 (54%) 的比例相似,但男性的无症状呈现率更高 (22%对9.1%).
- 女性报告了更多的肠外表现 (23.9%对12%) 和更大的十二指肠损伤 (p=0.021),而男性显示了更高的骨矿物密度变化的流行率 (p=0.017).
- 两性之间没有观察到对GFD的坚持有统计学意义的差异 (12%的女性和18%的男性报告了低/不坚持).
结论:
- 结核病诊断时临床表现的性别相关差异是最小的,并且随着一致的GFD遵守,在很大程度上减少.
- 无质饮食在缓解性别特异性症状概况方面似乎有效.
- 在成人乳患者中,对GFD的饮食遵守在性别之间没有显著差异.
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