母亲的托芬补充剂以性别特定的方式改变后代的肠脑轴和行为
Maria Carolina Fortunato1,2, João Neves1,3, Mariana Lapo Pais1,3
1Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal.
Journal of neurochemistry
|July 19, 2025
概括
孕产妇服用托芬补充剂对男性和女性不同影响后代的神经发育. 这种饮食干预影响了肠道微生物群,神经化学和行为,突出了肠道-大脑轴上的性别特异性影响.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 营养科学 营养科学
- 发展生物学 发展生物学
背景情况:
- 母亲的饮食极大地影响子女通过肠-大脑轴的神经发育.
- 氨酸是血清素的前体,对神经发育和免疫功能至关重要.
- 对神经精神疾病的性别特异性脆弱性与肠-大脑相互作用有关.
研究的目的:
- 为了研究母体托补充剂对后代肠道微生物群,新陈代谢,神经化学和行为的影响.
- 为了确定这些影响是否在健康后代的性别特异性.
主要方法:
- 分析了后代的微生物组成和代谢活性.
- 测量了大脑和血中的三甲酸和血清激素水平.
- 评估了雄性和雌性小鼠后代的行为结果.
主要成果:
- 母亲补充托芬诱导后代的性别特异性变化.
- 雌性后代表现出受损的微生物群,降低了大脑托/血清素,以及增加了焦虑.
- 男子后代表现出增加的新陈代谢活动,脑托的升高,和重复行为.
结论:
- 孕产妇补充的托芬调节了肠-大脑轴的组成部分,以取决于性别的方式影响后代的神经发育和行为.
- 研究结果强调了产前营养的重要性,并提出了神经发育健康的潜在性别特异性预防策略.
- 对有针对性的饮食干预措施进行进一步的研究是有必要的,以支持健康的神经发育和长期心理健康结果.
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