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在脊髓损伤后治疗神经病痛的 gabapentinoids:随机对照试验的更新元分析
Rafael Batista João1,2, Jilly Octoria Tagore Chan3, Ewen Shengyao Huang4
1Department of Neurology and Neurophysiology, Goiânia Neurological Institute, Goiânia, GO, Brazil.
概括
gabapentinoids 有效地减少中枢神经病痛 (CNP) 和改善脊髓损伤 (SCI) 患者的睡眠. 然而,这些药物增加了诸如视力模糊和头等不良事件的风险.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 脊髓损伤 (SCI) 经常导致中枢神经病痛 (CNP),这是一种使人衰弱的疾病.
- 加巴类药物通常用于SCI后的CNP,但它们的最佳使用仍然不确定.
研究的目的:
- 评估 gabapentinoids 与安慰剂的疗效和安全性,用于治疗 SCI 患者的 CNP.
主要方法:
- 进行了随机对照试验 (RCT) 的系统审查.
- 在PubMed,Embase和Cochrane图书馆数据库中搜索了与安慰剂比较 gabapentinoids (gabapentin,pregabalin,mirogabalin) 的研究.
- 分析了疼痛强度,睡眠干扰和不良事件.
主要成果:
- 包括五项涉及682名患者的RCT.
- 与安慰剂相比, gabapentinoids显著降低了平均每日疼痛和与疼痛相关的睡眠干扰.
- 接受 gabapentinoids 治疗的患者报告了更大的疼痛缓解 (≥50%) 和感知到的整体改善,但经历了增加的视力模糊,昏昏欲睡,周围和头.
结论:
- gabapentinoids 在缓解 CNP 的 SCI 患者的疼痛和改善睡眠方面表现出显著的有效性.
- 必须权衡 gabapentinoids 的益处与它们增加的不良事件风险.
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