葡萄牙使用和滥用精神药物的病死后果在葡萄牙
Ana Carmona Araújo1,2, Jose Pedro Guerreiro3, Carolina Bulhosa3
1iMed.ULisboa - Research Institute for Medicines, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal.
British journal of clinical pharmacology
|July 19, 2025
概括
在葡萄牙,滥用精神药物,通常与其他物质一起,导致严重的健康风险,包括严重的中毒和死亡. 公共卫生工作应针对高风险组合和药物类别,以减轻这些负面结果.
科学领域:
- 药物监测和公共卫生
- 毒理学和药物安全问题
- 药物使用的流行病学.
背景情况:
- 精神活性药物被广泛使用,但存在滥用和不良事件的风险.
- 了解与滥用精神药物相关的特定发病率和死亡率对于公共卫生干预至关重要.
- 多种物质的使用,包括酒精和非法药物,可以加剧滥用精神药物的风险.
研究的目的:
- 描述葡萄牙使用和滥用精神活性药物的发病率和死亡率后果.
- 估计与精神活性药物相关的各种不良结果的风险,包括死亡和急诊室入院.
- 确定构成最高风险的特定药物类别和组合.
主要方法:
- 多源数据库的回顾性分析.
- 对与精神药物相关的死亡,急诊室入院,严重中毒电话和药物不良反应的风险估计.
- 包括与酒精和非法药物共同使用的数据.
主要成果:
- 故意暴露于精神活性药物,特别是组合药物,抗抑郁药物和处方阿片类药物,经常导致严重中毒.
- 药物组合,抗抑郁药物和与酒精/非法药物共同使用的严重中毒风险增加.
- 与精神药物相关的死亡中有很大比例涉及这些药物的贡献,与酒精/非法药物联合使用和联合使用的风险更高. 由于滥用,二zepines/z-药物和抗抑郁药经常与急诊室的入院有关.
结论:
- 在葡萄牙,滥用精神活性药物往往与多种物质的滥用有关,导致严重的健康风险.
- 公共卫生战略必须优先考虑高风险的药物组合和与不良结果相关的治疗组.
- 建议将集成到卫生系统设计中的有针对性的预防工作来应对这些风险.
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