长期预防性抗生素给药对手术部位感染的影响:一个多中心的真实数据研究
Takeshi Yamada1, Akihisa Matsuda2, Takuya Nishino3
1Department of Gastroenterological Surgery, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan. y-tak@nms.ac.jp.
Surgery today
|July 19, 2025
概括
在消化器外科手术中,延长24小时以上的抗生素预防通常是无效和潜在的有害的. 遵守预防性抗生素指南对于预防手术部位感染 (SSI) 至关重要.
科学领域:
- 手术瘤学手术瘤学
- 预防传染病 预防传染病
- 临床药理学 临床药理学
背景情况:
- 指南建议在术后24小时内停止预防性抗生素治疗.
- 扩展预防有时用于高风险的消化器官手术,以预防手术部位感染 (SSI).
- 扩展预防的有效性和安全性需要进一步评估.
研究的目的:
- 评估接受长期抗生素预防的患者的特征.
- 评估扩展预防在消化器外科手术中预防SSI的有效性.
- 为了比较扩展和标准预防组之间的SSI发病率.
主要方法:
- 多中心回顾性研究分析了2938名接受选择性消化器外科手术的患者的索赔数据 (2021年1月至2023年12月).
- 主要终点:SSI (Clavien-Dindo等级≥2) 在术后30天内.
- 扩展预防 (≥术后3天) 和标准预防之间的SSI率的比较.
主要成果:
- 936名患者接受了延长的预防治疗;长时间的手术时间与其使用有关.
- 在大多数手术中,扩展预防并没有减少SSI发生率.
- 在接受长期预防的结肠癌患者中观察到更高的SSI发病率.
结论:
- 在消化器外科手术中,延长抗生素预防可能是无效和潜在的有害的.
- 调查结果强调了坚持基于证据的SSI预防指南的重要性.
- 优化抗生素使用对于患者安全和有效的感染控制至关重要.
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