植物性饮食指数和肝细胞癌的风险:来自前性队列研究的结果
Yen Thi-Hai Pham1,2, Renwei Wang1, Jaideep Behari3,4
1University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
International journal of cancer
|July 19, 2025
概括
健康的植物性饮食 (hPDI) 和整体植物性饮食指数 (PDI) 与中国新加坡人的肝细胞癌 (HCC) 风险降低有关. 这突出了预防HCC的潜在饮食策略.
科学领域:
- 营养科学 营养科学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 植物性饮食指数 (PDI) 评估食物摄入量的质量和数量,区分植物和动物来源.
- 关于PDI与肝细胞癌 (HCC) 风险之间的关联存在有限的数据.
- 饮食抑制剂的健康 (hPDI) 和不健康 (uPDI) 组成部分为饮食模式提供了细微的见解.
研究的目的:
- 为了前性地研究PDI,hPDI,UPDI和HCC风险之间的关联.
- 评估饮食模式在一个大型亚洲队列中HCC发展中的作用.
- 为HCC预防计划中的饮食干预提供证据.
主要方法:
- 未来的队列研究利用来自新加坡中国健康研究 (63275名参与者) 的数据.
- 根据基线食品频率问卷计算PDI,hPDI和UPDI.
- 通过记录链接确定了事件HCC病例,分析使用Cox比例危险回归,平均随访时间为17.6年.
主要成果:
- 总体PDI和HCC风险之间观察到一个反向关联 (HR每次SD增长:0.87;95%CI:0.79-0.95).
- 对于hPDI和HCC风险发现了类似的反向关联 (HR每次SD增长:0.86;95%CI:0.79-0.94).
- 在UPDI和HCC风险之间没有发现显著的关联.
结论:
- 对整体PDI和hPDI的更高遵守与患上HCC的风险降低有关.
- 这些发现支持将植物性饮食建议纳入HCC预防策略,特别是在亚洲人群中.
- 饮食质量,强调健康的植物食品,可能在减轻HCC发病率方面发挥关键作用.
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