母婴逆境对儿童行为和神经发育的代际影响:健康的MiNDS协议
Danilo Micali1,2, Ana Carolina Coelho Milani3,4, Camilla Salmeron5
1Laboratory of Integrative Neuroscience (LiNC), Universidade Federal de São Paulo, São Paulo, Brazil.
International journal of methods in psychiatric research
|July 19, 2025
概括
母亲的不良童年经历 (ACE) 可以影响孩子的神经发育和行为跨世代. 健康的MiNDS研究在巴西队列中调查了这些代际效应和生物机制.
科学领域:
- 发展心理学是发展心理学.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 母亲的不良童年经历 (ACE) 与孩子的负面结果有关.
- 了解代际影响和生物途径对于早期干预至关重要.
研究的目的:
- 研究母亲的ACE如何影响孩子的行为和神经发育.
- 探索这些代际影响背后的生物学机制.
- 检查与后代发育有关的产前炎症,压力和胎盘生物学.
主要方法:
- 健康的MiNDS队列招募了来自巴西低资源地区的母亲 (25-39周怀孕).
- 评估了母亲的ACE暴露 (高/低),并对新生儿进行了2年的跟踪.
- 从母亲和婴儿身上收集了生物样本,脑部MRI扫描和行为评估.
主要成果:
- 626名母亲参加;60%的人报告了三次或更多的ACE.
- 包括545个母婴双,303个MRI扫描和333个胎盘样本收集.
- 注册和6个月的随访已经完成; 后来的访问正在进行中.
结论:
- 健康的MiNDS数据使得测试母亲ACE和后代大脑行为发展之间的关联成为可能.
- 这项研究探讨了产前因素的作用,如炎症和胎盘生物学.
- 研究结果将阐明脆弱人群中健康风险的代际传播.
相关概念视频
Attention-Deficit/Hyperactivity Disorder
294
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
294
Socioemotional Development during Infancy
117
Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
Primary Temperament Types
Primary Temperament Types
117
Adler's Individual Psychology
1.2K
Alfred Adler, a prominent figure in psychology, founded the school of individual psychology. In contrast to Freud's emphasis on sexual or aggressive motives, Adler suggested that individuals are primarily motivated by their purposes and goals. He believed that people strive for perfection rather than pleasure. Adler argued that individuals could creatively act upon their genetic inheritance and environmental experiences to shape their own lives, emphasizing conscious motivation over...
1.2K
Human Genetics
730
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
730
Gene-Environment Interactions
517
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
517
Behavioral Genetics and Its Designs
524
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
524


