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Updated: Sep 14, 2025

Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers
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Monitoring Conformational Dynamics of Single Unmodified Proteins using Plasmonic Nanotweezers

Published on: March 21, 2025

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通过等离子体增强光揭示的单分子蛋白相互作用和展开

Roy W H Teeuwen1,2, Martina Russo1,2, Maarten Merkx3,2

  • 1Eindhoven University of Technology, Molecular Plasmonics group, Department of Applied Physics and Science Education, 5600 MB Eindhoven, The Netherlands.

Analytical chemistry
|July 19, 2025
PubMed
概括

这项研究引入了用等离子体增强的光显微镜,用于单分子蛋白相互作用分析. 这种新的方法揭示了以前未被观察到的相互作用异质性和蛋白质折叠动态.

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Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
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