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Updated: Sep 14, 2025

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SMAdd-seq:通过小分子DNA插曲和纳米孔序列测序来探测色素的可访问性.

Gali Bai1, Namrita Dhillon1, Colette Felton1

  • 1Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, United States.

Nucleic acids research
|July 19, 2025
PubMed
概括

我们开发了小分子引序列 (SMAdd-seq) 来绘制活细胞中DNA可访问性的地图. 这种纳米孔测序方法能够高精度地揭示染色质结构和动态.

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Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
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