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Updated: Sep 14, 2025

Single-Cell Quantification of Protein Degradation Rates by Time-Lapse Fluorescence Microscopy in Adherent Cell Culture
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Single-Cell Quantification of Protein Degradation Rates by Time-Lapse Fluorescence Microscopy in Adherent Cell Culture

Published on: February 4, 2018

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从体外代谢清除,蛋白质和细胞膜亲和性检测中估计体外半衰期

Carla Pou Miralbell1, Sandrine Desrayaud2, Berndt Oberhauser1

  • 1Global Discovery Chemistry, Novartis Biomedical Research, Novartis campus, WSJ-88.10.100, 4056, Basel, Switzerland.

ChemMedChem
|July 19, 2025
PubMed
概括

在体内预测药物半衰期仍然具有挑战性. 这项研究引入了结合细胞膜结合的新方程,改善了用于早期药物开发的体外试验的预测.

关键词:
智利 (CHI) 意大利 (IAM)半衰期 半衰期 半衰期人类血清白蛋白的人类血清白蛋白.微小体清除值 (microsomal clearance) 是一个非常小的清除值.模型 模型 模型 模型

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Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry08:52

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