跨癌症类型的PIK3CA异常的患病率和临床影响:现实世界的下一代测序方法

Junkyu Kim1, Hye-Lim Jang2, Jung Young Hong1

  • 1Division of Hematology-Oncology, Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea.

Cancer genetics
|July 19, 2025
PubMed
概括

在3886名患者中,PIK3CA突变在9.2%的患者中被发现,特别是结直肠癌患者. 这些突变与较高的瘤突变负担和微卫星不稳定性相关,为PIK3CA驱动的固体瘤提供了洞察力.

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