(III) 复合物作为I型光敏化剂用于缺氧双光子光动力学疗法
Zanru Tan1, Jiang Feng2, Zixin Tang1
1MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, Guangdong Basic Research Center of Excellence for Functional Molecular Engineering, School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, PR China.
Journal of inorganic biochemistry
|July 19, 2025
概括
新的复合物为治疗低氧黑色素瘤提供了一种新的方法,使用双光子光动力学疗法 (PDT). 这些不依赖氧气的光敏化剂有效地产生反应性氧物种 (ROS),诱导癌细胞死亡.
科学领域:
- 光动力学疗法 光动力学疗法
- 癌症研究 癌症研究
- 材料科学 材料科学 材料科学
背景情况:
- 光动力疗法 (PDT) 是一种有前途的皮肤癌治疗方法,但它面临着常规光敏化剂的局限性,包括依赖氧气和光线透性差.
- 瘤中缺氧状况对当前的PDT策略构成重大挑战.
研究的目的:
- 开发新型的 (III) 复合物作为I型光敏感剂,用于针对黑色素瘤的双光子PDT.
- 为了克服氧气依赖和改善光线透在PDT的低氧瘤.
主要方法:
- 合成和表征五种 (III) 复合物.
- 在低氧条件下对两光子吸收 (TPA) 截面和反应性氧物种 (ROS) 生成的评估.
- 评估细胞吸收,溶酶体和线粒体向和亡诱导.
- 在三维 (3D) 瘤球体中进行测试,以评估瘤透率和光毒性.
主要成果:
- 开发的 (III) 复合物在低氧条件下表现出显著的TPA截面 (≥100GM) 和高ROS产量.
- 在低氧条件下,Ir4@PEG在低IC50 (2.1μM) 和高PI (47) 的情况下显示出强烈的光毒性.
- Ir4@PEG针对溶解体,然后是线粒体,通过ROS生成诱导亡,并显示在3D球状体中瘤透的增强.
结论:
- 新型的 (III) 复合物作为有效的无氧光敏剂,用于双光子PDT.
- 这些发现为开发基于金属的双光子PDT药物治疗缺氧黑色素瘤提供了新的策略.
相关概念视频
01:27Photosystem I
64.4K
Although structurally similar to photosystem II (PSII), photosystem I (PSI) is has a different electron supplier and electron acceptor.
Both these photosystems work in concert. An excited electron from PSII is relayed to PSI via an electron transport chain in the thylakoid membrane of the chloroplast, which is comprised of the carrier molecule plastoquinone, the dual-protein cytochrome complex, and plastocyanin. As electrons move between PSII and PSI, they lose energy and must be re-energized...
Both these photosystems work in concert. An excited electron from PSII is relayed to PSI via an electron transport chain in the thylakoid membrane of the chloroplast, which is comprised of the carrier molecule plastoquinone, the dual-protein cytochrome complex, and plastocyanin. As electrons move between PSII and PSI, they lose energy and must be re-energized...
64.4K
01:22Photosystem II
72.6K
The multi-protein complex photosystem II (PS II) harvests photons and transfers their energy through its bound pigments to its reaction center, and ultimately to photosystem I (PSI) through the electron transport chain. The pigments responsible for caputirng the light energy in photosystems include chlorophyll a, chlorophyll b, and carotenoids.
The pigment molecules are arranged across two photosystem domains — the antenna complex and the reaction center. The main aim of the pigment...
The pigment molecules are arranged across two photosystem domains — the antenna complex and the reaction center. The main aim of the pigment...
72.6K
01:46Electron Transport Chain: Complex I and II
15.0K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
15.0K