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使用实验室制造的电极检测电子烟和生物样本中的合成大麻素的新型电化学方法

Cecília N F Barroso¹, Larissa M A Melo², Lívia M S Aranha³

¹Department of Chemistry, Federal University of Vales do Jequitinhonha and Mucuri, Campus JK, Diamantina, 39100000, Minas Gerais, Brazil.

|July 19, 2025

概括

使用添加的钻石电极的新电化学方法可以检测电子烟和生物样本中的强有力的合成大麻素受体激动剂 (SCRA),如AB-CHMINACA. 这种快速,有选择性的查工具解决了SCRA识别的关键公共卫生需求.

科学领域:

分析化学分析化学
法医毒理学法医毒理学
电化学电化学电化学

背景情况:

合成大麻素受体激活剂 (SCRA) 是一种强大的新型精神活性物质 (NPS),由于广泛使用和过量可能,具有重大法医和公共卫生影响.
现有的标准化查方法在法医和毒理学背景下缺乏SCRA检测.
像AB-CHMINACA和MDMB-4en-PINACA这样的SCRAs由于它们的高强度和与CB1和CB2受体的相互作用而引起严重关注.

研究的目的:

引入和验证一种用于选择性和准确检测SCRAs的新型电分析方法.
为了全面识别,研究AB-CHMINACA和MDMB-4en-PINACA的电化学行为.
在复杂矩阵中建立一个快速而敏感的SCRA查方法.

主要方法:

开发一种使用实验室制造的合金钻石丝印电极 (SP/BDDE) 的新型电分析方法.
方波吸附剥离电压测量 (SWAdSV) 的应用用于SCRA检测.
对SCRA电化学行为的全面调查,利用所有氧化还原过程进行识别.

主要成果:

拟议的方法显示了广泛的线性范围 (AB-CHMINACA的20-100μM,MDMB-4en-PINACA的20-70μM) 和低的检测极限 (0.282μM).
通过干扰研究证实了高选择性,电化学参数的相对标准偏差低于10%.
在电子烟和生物样本中成功识别了AB-CHMINACA和MDMB-4en-PINACA,几乎100%的回收率,表明矩阵效应最小.

结论:

开发的SP/BDDE-SWAdSV方法为SCRA提供了一个有希望的,快速和选择性的查方法.
该方法非常适用于涉及扣押样品和生物标本毒理学分析的法医应用.
这些发现解决了在法医和毒理学场景中对标准化和有效的SCRA检测的关键需求.

关键词:

这里是AB-CHMINACA.用添加合剂的钻石.在MDMB-4en-PINACAA中使用.口服液体是指口服液体.用丝网打印的电极.

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