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Updated: Sep 14, 2025

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卡苏米-1外基因组在TP53型急性白血病中起着T细胞免疫逃避的主要作用

Yunyun Du1, Zhenfeng Fan2, Lijiao Li1

  • 1Hematopathology Department, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, PR China.

Immunobiology
|July 19, 2025
PubMed
概括

突变TP53急性白血病 (AL) 外基因组通过增加PD-L1和改变T细胞种群来促进免疫逃生. 卡苏米-1外体显著减少CD8+T细胞和增加Tregs,导致不利的AL预后.

关键词:
患有急性白血病的人.外基因组是外基因组的组成部分.免疫逃脱是为了逃脱免疫.在PD-1/PD-L1中.这种突变是TP53突变.在 miRNA 测序过程中,

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