人类在受污染地区暴露于PFAS:水和血清水平之间的关联
Anna Maria Ingelido1, Valentina Fuscoletti2, Annalisa Abballe1
1Istituto Superiore di Sanità, Dipartimento Ambiente e Salute, Rome, Italy.
Chemosphere
|July 19, 2025
概括
和多化物质 (PFAS) 是广泛使用的工业化学品. 这项研究发现水是PFAS暴露的主要来源,摄入量往往超过安全限值,并确定女性的排泄速度更快.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 和多化物质 (PFAS) 是持久性工业化学品,具有潜在的毒性作用.
- 广泛使用和环境持续导致全球PFAS污染.
- 人类暴露的途径和决定因素需要调查,特别是在受污染的地区.
研究的目的:
- 调查PFAS污染水热点中人类暴露于PFAS的决定因素.
- 检查水中的PFAS度与人体血清之间的关系.
- 分析影响人类PFAS消除率的因素.
主要方法:
- 研究了600平方公里面积的15万居民和PFAS水污染.
- 在饮用水和参与者血清中测量PFAS度.
- 估计每周的PFAS摄入量,血清与水的比率,以及清除因子.
主要成果:
- 水被证实是研究区域PFAS暴露的主要来源.
- 大多数参与者超过了欧洲食品安全局每周可容忍的PFAS摄入量.
- 血清与饮用水的比率差异很大,男性的清除率低于女性.
结论:
- 人类通过受污染的水接触PFAS是严重的公共卫生问题.
- 在PFAS消除率中观察到基于性别的差异,这表明女性清除速度更快.
- 调查结果可以为PFAS预防和环境修复的战略提供信息.
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