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结直肠癌中的纤维细胞激活蛋白表达和临床应用的含义

Meaghan Polack¹, Gabi W van Pelt¹, Augustinus S L P Crobach²

¹Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands.

Cancer treatment and research communications

|July 19, 2025

概括

结肠直肠癌 (CRCs) 表达纤维细胞激活蛋白 (FAP),但表达水平有很大差异,与瘤筋膜比率无关. 这凸显了在CRC中仔细解释FAPI成像的需要.

科学领域:

在瘤学瘤学.
病理学病理学病理学
医疗成像医学成像

背景情况:

大肠直肠癌 (CRC) 是一种普遍存在的恶性瘤.
瘤微环境,特别是与癌症相关的纤维细胞 (CAFs),在CRC进展中起着至关重要的作用.
纤维细胞激活蛋白 (FAP) 是CAF的标记物,是通过放射性标记的FAP抑制剂 (FAPI) 进行成像的有希望的目标.

研究的目的:

为了研究结直肠癌中FAP表达的模式.
评估FAP表达和内肌层量 (瘤-肌层比,TSR) 之间的关联.
在CRC病理学中为基于FAPI的成像提供生物背景.

主要方法:

对125名II/III期CRC患者的档案资料进行了组织学分析.
使用血素和素染色来确定瘤-肌瘤比率 (TSR).
通过免疫组织化学对FAP表达的半定量评分.
基平方测试用于评估TSR和FAP表达之间的相关性.

主要成果:

在包括的93名患者中,84%的CRC显示出一些FAP表达,主要是在侵入性前线.
在87%的相关淋巴结转移中检测到FAP表达.
在高流体CRC和高FAP表达 (P = 0.428) 之间没有发现显著的相关性.
FAP表达通常是异质的,甚至在健康的组织中也观察到.

结论:

大肠直肠癌和淋巴结转移通常表达FAP,但具有显著的瘤间和瘤内变异性.
FAP表达水平与瘤-肌瘤比率没有直接相关.
建议在翻译有关疾病范围和活动的FAPI-PET/CT发现时谨慎使用,强调需要采用多学科方法.

关键词:

与癌症相关的纤维细胞.结肠直肠癌是一种癌症.纤维细胞激活蛋白质的激活蛋白质免疫组织化学免疫组织化学瘤-肌瘤比率是什么

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