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甲状腺干扰和与斑马鱼胚胎暴露于海姆克萨的多毒性终点的关联

Lili Niu¹, Zhouchi Zhang², Kan Zhang³

¹Zhejiang Collaborative Innovation Center for Full-Process Monitoring and Green Governance of Emerging Contaminants, Interdisciplinary Research Academy (IRA) and College of Biological and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China.

Ecotoxicology and environmental safety

|July 19, 2025

概括

甲状腺激素调节在斑马鱼中被破坏,导致发育问题和氧化应激. 这种农药干扰关键基因,影响黑色素的产生,并带来生态风险.

科学领域:

环境毒理学环境毒理学
内分泌学在内分泌学.
发展生物学发展生物学

背景情况:

甲状腺激素 (TH) 干扰是开发过程中农药毒性的关键因素.
甲醇 (HM) 是一种具有潜在环境风险的杀菌剂,但其内分泌干扰作用尚不清楚.

研究的目的:

为了研究HM在斑马鱼胚胎中的甲状腺破坏潜力.
检查HM与发育性毒性,黑色素生物合成和氧化应激的相互作用.

主要方法:

斑马鱼胚胎暴露于HM.
分析TH水平和下丘脑-垂体-甲状腺 (HPT) 轴的基因表达.
分子对接,转录组分析和氧化应激生物标志物的评估.

主要成果:

HM暴露降低了TH水平和调节不良的HPT轴基因 (DEIO1,DEIO2,TRα,TTR,UGT1ab).
HM对TSHβ具有很高的结合亲和力,证实其作为甲状腺破坏者的作用.
由HM引起的TH耗竭与发育异常和活动受损相关.
HM减少了黑色素沉积,并诱导了氧化应激,影响了抗氧化酶和MDA/GSH水平.

结论:

HM作为甲状腺干扰剂,通过TH调节影响斑马鱼的发育.
在HM,TH破坏,黑色素生物合成和氧化应激之间存在复杂的相互作用.
这些发现提高了对农药诱导的内分泌干扰和生态后果的理解.

关键词:

对水生有毒性的水生毒性黑色素是黑色素的一种.氧化应激是一种氧化应激.杀虫剂是一种杀虫剂.甲状腺功能障碍甲状腺功能障碍

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