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Updated: May 6, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
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在当代综合风险评估中遗留的hERG研究数据 - 缓解协议和积极对照文章差异风险

Richard W Daniels1, James W Kramer1, Matthew M Abernathy2

  • 1Charles River Laboratories, Cleveland Inc., Cleveland, OH, USA.

Journal of pharmacological and toxicological methods
|July 19, 2025
PubMed
概括

使用人类以太基因相关基因 (hERG) 通道测试的常规心脏安全评估可能不需要重复. 研究表明,使用传统协议与更新的最佳实践相比,使用hERG安全边际或功效没有显著差异,特别是用terfenadine作为对照.

关键词:
锡萨普里德 (Cisapride) 是一种在每一天的时间里,做一些事情.莫西弗洛克萨辛 (moxifloxacin) 是一种药物.在 Ondansetron 中.特尔芬阿丁 (terfenadine) 是一种药物.赫尔格 (hERGG) 是一个

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