初级甲状腺功能障碍症的管理:历史和当代的观点
Sheryl T Y Htoo1, Natalie E Cusano1
1Division of Endocrinology, Department of Medicine, Zucker School of Medicine at Hofstra/Northwell, New York, New York.
概括
原发性副甲状腺炎症 (PHPT),通常是由副甲状腺腺瘤引起的,由于查,越来越多的患者被诊断为无症状. 建议在有症状的病例中进行手术,而在其他病例中,医学疗法可以治疗并发症.
科学领域:
- 内分泌学 在内分泌学.
- 生物化学 生物化学
- 遗传学 遗传学 是一个
背景情况:
- 原发性副甲状腺症 (PHPT) 是一种常见的内分泌疾病,通常是由副甲状腺腺瘤引起的.
- 由于生物化学查,PHPT的流行病学和管理已经发展,无症状的呈现现现在在发达国家普遍存在.
- 正常血性PHPT是一个诊断挑战,需要排除二次原因.
研究的目的:
- 审查不断发展的流行病学和初级甲状腺功能障碍症的管理策略.
- 突出诊断标准血性PHPT的考虑因素和遗传检测的作用.
- 概述当前的治疗建议,包括手术和医疗选择.
主要方法:
- 对PHPT的流行病学趋势和诊断标准的文献综述.
- 分析目前手术和医疗管理的指导方针.
- 在特定患者群体中讨论基因测试的实用性.
主要成果:
- 无症状的PHPT是发达国家最常见的表现; 全球范围内症状性疾病正在减少.
- 基因检测有助于在选定的年轻患者中区分PHPT与家族性低血性高血症.
- 许多"无症状"的患者有未被诊断的并发症,如腎病或脊椎骨折.
结论:
- 手术仍然是有症状的PHPT和选择的无症状病例的主要治疗方法.
- 在非手术候选人的高血症和骨质疏松症中,可以使用cinacalcet和抗吸收疗法进行医疗管理.
- 综合评估,包括对并发症的查,对于最佳的PHPT患者管理至关重要.
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