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验证自由光链参考间隔及其与年龄和eGFR的关联

Junyi Wu¹, Xiaowen Zheng², Yilin Ge¹

¹Department of Laboratory Medicine, Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, Beijing 100029, China.

Clinica chimica acta; international journal of clinical chemistry

|July 19, 2025

概括

血清自由光链 (FLC) 和 κ/λ比率 (FLCR) 的参考间隔在健康的中国成年人中确定. 随着年龄的增长,FLC水平增加,并随着估计的淋巴膜过率 (eGFR) 降低.

科学领域:

临床化学临床化学
免疫学免疫学免疫学
腎臟病學 (nephrology) 是一種醫學.

背景情况:

无血清 κ 和 λ 轻链 (FLC) 和它们的比率 (FLCR) 是重要的生物标志物.
建立特定人群的参考间隔 (RIs) 对于准确的临床解释至关重要.
年龄和功能等因素可能会影响FLC水平.

研究的目的:

确定中国健康成年人血清FLC和FLCR的参考间隔.
调查年龄和估计的膜过率 (eGFR) 对这些参数的影响.

主要方法:

在549名健康成年人中,用于测量FLC的nephelometric测试,其eGFR>90mL/min/1.73m2.
参考间隔是使用第2.5至97.5百分位数计算的.
斯皮尔曼相关性和回归分析评估了FLCs,FLCR,年龄和eGFR之间的关系,包括具有降低eGFR的子组.

主要成果:

已确定的 RI: κ-FLC 4.27-35.05 毫克/升, λ-FLC 12.61-34.09 毫克/升, FLCR 0.15-1.58.0 毫克/升.
所有FLC参数都显示出与eGFR的反相关性 (p < 0.001).
随着年龄的增长,FLC参数增加 (p < 0.001).

结论:

来自其他种群或测试的参考间隔可能不适用于所有人.
年龄和功能显著影响血清FLC和FLCR水平.
对FLC结果的临床解释需要考虑患者的年龄和状况.

关键词:

免费提供轻链.参考间隔的参考间隔.美国GFRGFR

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