富科伊丹修改用于稳定的黑激素O/W乳液:界面结构和特性
Yanan Zhao1, Yitong Wang1, Fei Yu1
1College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang 524088, China.
International journal of biological macromolecules
|July 19, 2025
概括
这项研究用2-Octen-1-ylsuccinic anhydride (OSA) 和超声波修改了fucoidans (FUCs),创造了一个稳定的乳液,用于黑激素的输送. 优化的富可伊丹乳液增强了黑激素.
科学领域:
- 食品科学与技术 食品科学与技术
- 材料科学 材料科学 材料科学
- 生物化学 生物化学
背景情况:
- 富可伊丹 (FUC) 是具有潜在乳化特性的多糖化合物.
- 修改fucoidans可以提高它们在传递系统中的功能.
- 黑色素是一种具有有限生物可用性的生物活性化合物.
研究的目的:
- 为了研究2-Octen-1-ylsuccinic无水化物 (OSA) 修饰和超声波对富可伊丹 (FUC) 结构和乳化物的影响.
- 开发一种稳定的多糖体乳液系统,以增强黑激素的输送.
- 评估乳液对黑激素生物可访问性和释放动态的影响.
主要方法:
- 使用2-Octen-1-ylsuccinic无水化物 (OSA) 修改了Fucoidan.
- 对修改后的富可伊丹乳液进行了超声波治疗.
- 测量了界面张力,滴滴大小和储存稳定性.
- 评估了黑色素的生物可访问性和自由脂肪酸 (FFA) 的释放.
主要成果:
- OSA修饰和超声波改善了福科伊丹的两性和减少了面际张力.
- 使用400W超声波处理的9%-OSA-FUCs乳液呈现出最小的水滴大小 (1.34 ± 0.03μm).
- 乳液系统显著提高了黑激素的生物可访问性 (55.32%) 并延迟了FFA的释放.
结论:
- 用OSA和超声波合理修改fucoidans,可以创建高度稳定的乳液.
- 这种输送系统有效地保护黑激素免受胃肠道环境的影响,改善吸收.
- 这些发现为设计功能性多糖基乳化剂和疏水化合物的输送系统提供了洞察力.
相关概念视频
Membrane Fluidity
156.6K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
156.6K
Colloids
17.9K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
17.9K
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
268
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
268


