长期COVID中慢性炎症与自身免疫性疾病的关系
Keda Chen1, Zhiyi Wang1, Jiaxuan Li1
1Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, PR China.
Autoimmunity reviews
|July 19, 2025
概括
长期COVID是冠状病毒感染后的一种持续性疾病,可能源于慢性炎症,并引发自身免疫性疾病. 本综述探讨了这些联系和潜在的免疫疗法,以帮助患者康复.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 病理生理学 病理生理学
背景情况:
- 随着COVID-19的流行,长期COVID出现,其特点是持续数月至数年的多系统性后续.
- 慢性炎症,可能是由残留的病毒成分驱动的,被怀疑是长期COVID的潜在机制.
- 了解长期COVID中慢性炎症和自身免疫性疾病之间的联系至关重要.
研究的目的:
- 在长期COVID的背景下,审查与慢性炎症相关的自身免疫疾病.
- 阐明导致长期COVID相关自身免疫的病理生理机制.
- 为长期COVID患者提供免疫疗法策略的参考.
主要方法:
- 文献综述侧重于慢性炎症,自身免疫性疾病和长期COVID.
- 对拟议的病理生理路径的分析,包括细胞因子风暴,炎症囊泡,巨细胞激活,肠道失调,分子模拟,病毒活性和凝血异常.
- 检查潜在的治疗干预措施,如益生菌,免疫球蛋白和免疫调节药物.
主要成果:
- 已确定为导致自身免疫性疾病的慢性炎症途径,如系统性红斑狼,吉林巴雷综合征和类风湿性关节炎.
- 讨论的具体机制包括细胞因子风暴,炎症囊泡激活,巨细胞激活综合征,肠道微生物群变化,分子模仿,潜伏病毒活性化和凝血问题.
- 考虑了潜在的免疫治疗方法和临床试验模型 (例如,RECOVER).
结论:
- 慢性炎症是长期COVID中自身免疫后续发展的关键因素.
- 针对这些炎症途径为长期COVID免疫疗法提供了一个有希望的途径.
- 对这些机制的进一步研究可以为患有长期COVID并发症的患者提供有效的治疗策略.
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