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化应激和内皮损伤对血管侵入性乳头甲状腺癌的影响

Angelika Buczyńska¹, Maria Kościuszko², Agnieszka Adamska²

¹Clinical Research Centre, Medical University of Bialystok, 15-276, Bialystok, Poland. angelika.buczynska@umb.edu.pl.

Scientific reports

|July 19, 2025

概括

在乳头甲状腺癌 (PTC) 中的血管侵袭可能会使结果恶化. 这项研究确定了关键标记物,如3-甲酸铁素 (3-NT) 和胎盘生长因子 (PLGF),以预测血管侵袭,提高预后准确度.

科学领域:

在瘤学瘤学.
生物化学生化学
病理学病理学病理学

背景情况:

乳头甲状腺癌 (PTC) 通常有良好的预后,但血管侵袭可能导致侵袭性疾病.
确定血管侵袭的标志物对于定制治疗至关重要,包括放射性治疗 (RAI).
化应激和内皮损伤是血管侵入性PTC中涉及的途径.

研究的目的:

为了确定与PTC中血管侵袭相关的新生物标志物.
调查化应激和内皮损伤标志物在血管侵入性PTC中的作用.
评估这些标记物的潜力,作为患者管理的预后指标.

主要方法:

评估的总抗氧化能力 (TAC),3-尼托铁素 (3-NT),胎盘生长因子 (PLGF),整合素亚单元α V (ITGAV) 和ITGαVβ3.3的水平.
在45名血管侵入性PTC患者和45名非血管侵入性PTC患者之间比较标记水平.
利用后勤回归分析,并计算曲线下的面积 (AUC) 以获得标记的显著性.

主要成果:

在血管侵入性PTC患者中发现3-NT,PLGF,ITGAV和ITGαVβ3水平升高.
与对照组相比,血管侵入性PTC组观察到TAC水平下降 (p < 0.05).
一个由3-NT,TAC和PLGF组成的组合小组显示,对血管侵袭有很高的诊断效用 (AUC=0.95).

结论:

在PTC中,TAC,3-NT和PLGF与血管侵袭有显著的关联.
作为血管侵袭的标志物,PLGF显示出临床意义 (AUC = 0.82).
一个多标记面板 (3-NT + TAC + PLGF) 在PTC管理中为血管侵入提供了增强的查潜力.

关键词:

血管侵袭是一种血管侵袭.子宫内膜损伤的损伤.亚酸性压力是一种压力.乳头甲状腺癌是一种乳头甲状腺癌.

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