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Updated: Sep 14, 2025

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
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Published on: January 17, 2012

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过度表达TFEB可缓解由progranulin不足引起的自-溶酶缺陷

Wren O Nader1, Kaylan S Brown1, Nicholas R Boyle1

  • 1Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer's Disease Center, Evelyn F. McKnight Brain Institute, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.

Scientific reports
|July 19, 2025
PubMed
概括

进子素 (GRN) 突变通过损害 lysosomal 功能导致前性痴呆症 (FTD). TFEB激活有助于纠正这些缺陷,这表明基于溶酶体的疗法可以治疗GRN相关的FTD.

关键词:
自自是一种自的过程.Lysosomes 是一个溶解体.益格拉努林是一种Progranulin.美国联邦税务法 (TFEB)

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