基于α-环氧德克斯/素光的-维生素D联合输送水溶液系统的结构特征和构造分析
Yifu Zhang1, Jiawang Zhang2, Yuanda Zhao2
1College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China; College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
Food chemistry
|July 20, 2025
概括
一个新型的水系统使用四元复合体共同提供离子 (Ca2+) 和维生素D (VD). 这提高了它们的稳定性和在肠道中的协同释放.
科学领域:
- 材料科学 材料科学 材料科学
- 生物化学 生物化学
- 营养科学 营养科学
背景情况:
- 维生素D3 (VD3) 和离子 (Ca2+) 对骨健康至关重要.
- 由于个体稳定性和生物可用性问题,它们的共同交付和协同释放存在挑战.
研究的目的:
- 开发一种用于VD3和Ca2+的水性联合输送系统.
- 为了实现VD3和Ca2+的协同加载和释放.
- 为了提高两种营养素的稳定性和生物可用性.
主要方法:
- 一个四元复合物的制备:α-cyclodextrin-VD3@casein 酸-酸 (α-CD-VD3@CPP-Ca2+).
- 粒子大小 (419.46 ± 1.52 nm) 和泽塔电位 (-28.39 ± 1.21 mV) 的表征.
- 谱分析以确定结合力 (键,范德瓦尔斯力).
- 在各种pH值和盐离子条件下评估分散性和稳定性.
- 在实验室释放模拟胃液 (SGF) 和模拟肠液 (SIF) 的研究.
主要成果:
- α-CD-VD3@CPP-Ca2+复合体表现出良好的水性分散性和增强的稳定性.
- 在SGF方面,该综合体保持稳定.
- 在SIF中实现了高释放效率:78.39%的VD3和84.12%的Ca2+.
结论:
- 开发的四元复合体是VD3和Ca2+的有效水性联合输送系统.
- 该系统增强了VD3和Ca2+的协同利用.
- 这种方法为改善营养物质的输送和吸收提供了一个有希望的解决方案.
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