聚烯微型和纳米塑料:对对 Mytilus galloprovincialis 的细胞毒性作用进行比较研究
R Romano1, L Rosati2, G Napolitano1
1Department of Science and Technology, University Parthenope, Napoli, Italy; International PhD Programme, UNESCO Chair "Environment, Resources and Sustainable Development", Department of Science and Technology, Parthenope University of Naples, Naples 80143, Italy.
Ecotoxicology and environmental safety
|July 20, 2025
概括
聚烯微塑料 (MP) 和纳米塑料 (NP) 通过损伤状组织和损害状功能来伤害地中海 (Mytilus galloprovincialis). 纳米塑料显示出更严重的细胞毒性影响,突显了急需减少塑料的迫切需要.
科学领域:
- 环境毒理学环境毒理学
- 海洋生物学 海洋生物学
- 生态毒理学 生态毒理学
背景情况:
- 水生生态系统面临着由持久聚烯微塑料 (MP) 和纳米塑料 (NP) 造成的严重污染.
- 地中海料动物Mytilus galloprovincialis是环境污染物的关键生物指标.
- 由于其持久性和可能进入食物链,MP和NP对海洋生物和人类健康构成风险.
研究的目的:
- 评估聚乙烯MP (5微米) 和NP (0.1微米) 对Mytilus galloprovincialis囊细胞解剖学的细胞毒性作用.
- 评估MP和NP暴露对氧化应激生物标志物和贝中的组织学变化的影响.
主要方法:
- 成年Mytilus galloprovincialis被暴露在聚烯MP和NP中1,3天和11天.
- 评估了活性氧物种 (ROS),脂质过氧化,抗氧化能力和组织学变化 (上皮细胞变化,原沉积,免疫细胞存在).
- 量化增殖标记PCNA表达和观察到对状结构的影响.
主要成果:
- 增加ROS,氧化脂损伤和体外氧化剂敏感性,在第3天观察到.
- 在第3天和第11天观察到总抗氧化能力的提高.
- 组织学分析显示了从第一天开始的上皮细胞变化,PCNA表达增加,原沉积,免疫细胞透和粘液细胞增加.
- 纳米塑料 (NP) 产生的效果比微塑料 (MP) 更为明显.
- 功能显著受损,包括由于毛损伤而降低了食物收集效率.
结论:
- 聚烯MP和NP在Mytilus galloprovincialis的中引起显著的细胞毒性作用和组织学损伤.
- 与微塑料相比,纳米塑料具有更大的毒性.
- 该研究强调了微塑料和纳米塑料对海洋生物的有害影响,并强调迫切需要减少塑料污染.
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