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Updated: Sep 14, 2025

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针对GPR119和DPP-4的5-甲氧皮里米丁衍生物的设计,合成和抗糖尿病活性

Fukang Yang1, Sumei Shi2, Shaobing Cheng1

  • 1National Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Chinese Medicine, Nanchang 330006, China.

Bioorganic & medicinal chemistry
|July 20, 2025
PubMed
概括

研究人员开发了针对2型糖尿病 (T2DM) 的双重目标化合物. 化合物27有效抑制了二乙酶-4 (DPP-4) 和激活G蛋白结合受体119 (GPR119),显示了T2DM治疗的前景.

关键词:
抗糖尿病活动 抗糖尿病活动在DPP-4中使用.双重目标化合物是双重目标的化合物.在GPR11919中使用.

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