慢性淋巴细胞白血病患者BTKi治疗心血管不良事件的实践管理:血液学家和心脏学家的共识报告
Acta haematologica
|July 20, 2025
概括
对慢性淋巴细胞白血病 (CLL) 患者进行布鲁顿治疗的管理心血管风险,如心房动和高血压至关重要.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 包括心房动和高血压在内的心血管不良事件在治疗慢性淋巴细胞白血病 (CLL) 患者中被观察到,这些患者使用布鲁顿的氨酸激酶抑制剂 (BTKis).
- 现有的管理这些不良事件的指导方针在不同地区和临床环境的实际应用中显示出不一致.
- 需要标准化建议来解决这些管理不一致的问题.
研究的目的:
- 为在接受BTKi治疗的CLL患者中对心房动 (AF) 和高血压的查,监测和治疗制定共识建议.
- 为管理与BTKi治疗相关的心血管毒性提供实际指导.
- 通过解决相关心血管风险,确保有效的CLL治疗的连续性.
主要方法:
- 召集一个由血液学家和心脏病学家组成的欧洲专家小组.
- 进行全面的文献分析.
- 利用专家采访和德尔菲方法,就有关AF和高血压管理的关键陈述达成共识.
主要成果:
- 关于在BTKi治疗中治疗CLL患者的AF和高血压的查,监测和治疗策略的共识陈述.
- 建立了癌症治疗相关心血管毒性风险分层系统 (低,中等,高,非常高风险).
- 推患者教育,用于症状监测和在家监测血压和心电图.
结论:
- 维持BTKi治疗对于最大限度地延长CLL患者下一次治疗的时间至关重要.
- 适当管理高血压和AF,以及潜在的BTKi剂量调整,可以帮助维持高风险患者的治疗.
- 血液学家和心脏病学家之间的密切合作对于优化患者的治疗结果和确保有效的CLL治疗以及心血管护理至关重要.
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