在接受COVID-19疫苗接种的甲状腺功能障碍患者中,患甲状腺眼病的风险
Linus Amarikwa1, Patcharaporn Chandraparnik2, Karen M Wai3
1Department of Ophthalmology, Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, United States.
概括
mRNA COVID-19 疫苗接种与甲状腺眼病 (TED) 的高风险有关,这种风险在甲状腺功能障碍症患者中较高. 患有自身免疫性甲状腺疾病的个人应注意接种疫苗后的TED症状.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺眼病 (TED) 是一种影响眼睛的自身免疫性疾病,通常与甲状腺功能障碍有关.
- 由于mRNA COVID-19疫苗已被广泛使用,因此需要了解其潜在的副作用,特别是在弱势群体中.
研究的目的:
- 评估mRNACOVID-19疫苗接种与甲状腺眼病 (TED) 在被诊断为甲状腺功能障碍症的患者中的发病率之间的关联.
- 将COVID-19疫苗接种后的TED风险与其他常见疫苗 (如流感和Tdap) 的风险进行比较.
主要方法:
- 使用TriNetX网络进行的一项回顾性队列研究.
- 纳入标准:患有甲状腺功能障碍的患者,在2021年3月之前没有以前的TED或轨道炎症性疾病.
- 倾向分数匹配 (PSM) 用于控制混的人口统计学和并发症变量.
主要成果:
- 这项研究确定了373,909名甲状腺功能障碍患者;在PSM后包括了69,378名患者.
- 与没有接种COVID-19疫苗 (RR=1.49) 相比,COVID-19疫苗接种与患TED的风险增加49%有关.
- 与没有接种COVID-19疫苗相比,Tdap (RR=1.80) 和流感 (RR=1.68) 接种后TED的风险也增加了.
结论:
- 患有甲状腺功能障碍的患者在接种mRNA COVID-19疫苗后,患有TED的风险增加.
- 需要进一步的研究来证实这些发现.
- 患有自身免疫性甲状腺疾病的个体应接受有关TED症状的教育,并在接种疫苗后进行监测.
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