在大鼠中,因皮肤上和鼻腔内暴露于因多克萨卡布而引发的潜在风险
Eman I Hassanen1, Marwa H Hassan2, Ahmed M Hussien3
1Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.
Toxicology and applied pharmacology
|July 20, 2025
概括
暴露在昆虫杀虫剂Indoxacarb中导致大鼠的器官损伤. 皮肤暴露导致肝酶水平升高和器官损伤,而鼻腔暴露主要影响肺部和免疫器官.
科学领域:
- 毒理学 毒理学 毒理学
- 环境健康 环境健康
- 杀虫剂安全性 杀虫剂安全性
背景情况:
- 印多克萨卡布 (IDX) 是一种选择性杀虫剂,广泛用于对抗害虫.
- 评估人类和动物健康的潜在危害需要了解印多克萨卡伯的吸收途径.
研究的目的:
- 评估大鼠在皮肤和鼻腔粘膜中吸收的印多克萨卡布.
- 通过不同的途径评估因多克萨卡布暴露的毒理影响和潜在危险.
主要方法:
- 28只雌性Wistar大鼠被分为四组:盐水控制组 (鼻内和局部) 和induxacarb (鼻内和局部).
- 分析了血清生化标志物 (ALT,AST,CPK,LDH,IgG,IgM) 和他的病理学变化.
- 使用caspase-3 (casp-3) 免疫染来确认细胞损伤.
主要成果:
- 局部用印克萨卡伯 (IDX-T) 组显示ALT,AST,CPK和LDH水平升高,皮肤,肝脏,心脏和肺部有显著的组织病理损伤.
- 鼻腔内因多卡 (IDX-IN) 组表现出较低的IgG和IgM水平,肺部,免疫器官和大脑的病变.
- 在IDX-T组的肝脏,心脏和肺部,在IDX-IN组的肺部,脏,胸腺和大脑中,Caspase-3的表达更高.
结论:
- 皮肤和鼻腔接触印多克萨卡布可以导致大鼠显著的器官毒性.
- 皮肤暴露似乎会诱导更多的全身毒性,特别是影响肝酶和心脏/肺组织.
- 鼻内暴露对呼吸系统,免疫功能和中枢神经系统构成风险.
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