巴卡里斯dracunculifoliaDC的尿液和效应. (阿斯特拉属植物)
Valter Paes de Almeida1, Sara Emília Lima Tolouei2, Lislaine Maria Klider2
1Laboratory of Pharmacognosy, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, PR, Brazil.
Journal of ethnopharmacology
|July 20, 2025
概括
传统上用于治疗疾病的Baccharis dracunculifolia叶没有急性毒性. 一种水性提取物 (ESBD) 在老鼠中表现出尿和效应,支持其药用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 民族植物学 民族植物学
- 自然产品 化学 化学
背景情况:
- 巴卡里斯 (Baccharis dracunculifolia) (Asteraceae),也称为阿莱克里姆-多-坎波 (alecrim-do-campo),是一种巴西药用植物.
- 传统上用于各种疾病,包括心血管问题,其心血管效应缺乏科学验证.
研究的目的:
- 为了研究B. dracunculifolia空气部件的水性提取物 (ESBD) 和精油 (EOBD) 的心性质.
- 评估ESBD和EOBD在Wistar大鼠中的安全性和潜在的利尿和低血压作用.
主要方法:
- EOBD (GC-MS) 和ESBD (LC-DAD-HRMS) 的化学组成分析.
- 在雌性Wistar大鼠中对ESBD和EOBD进行急性毒性测试.
- 评估ESBD和EOBD (30-300毫克/公斤) 在正常血压的雄性Wistar大鼠中的利尿和低血压作用.
主要成果:
- EOBD主要含有单烯碳化合物 (例如β-烯,烯).
- 在ESBD中含有黄和酸衍生物 (例如酸).
- 没有观察到急性毒性;LD50>2000mg/kg. ESBD (300 mg/kg) 显著增加尿液体积和/分泌量.
结论:
- B. dracunculifolia 提取物 (ESBD 和 EOBD) 在急性服用时是安全的.
- ESBD 具有利尿和水性质,支持其传统用于心血管和脏健康的用途.
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