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从惰性到生物活性:设计的表面可以抑制口腔癌细胞的增殖和迁移

Evelina Herendija¹, Milica Jakšić Karišik², Marijana R Pantović Pavlović³

¹University of Belgrade, Multidisciplinary PhD Studies, Biomedical Engineering and Technology, Studentski Trg 1, 11000, Belgrade, Serbia.

Chemico-biological interactions

|July 20, 2025

概括

一种新的植入物涂层通过诱导亡和氧化应激,有效地对抗口腔癌细胞. 这种先进的材料显示出局部化术后治疗口腔状细胞癌 (OSCC) 的潜力.

科学领域:

生物材料科学生物材料科学
癌症生物学癌症生物学
纳米技术纳米技术

背景情况:

植入物广泛用于口腔手术,但它们与生物环境的相互作用可以进一步优化.
口腔状细胞癌 (OSCC) 是一个重大挑战,需要创新的治疗策略.
开发具有固有的抗癌性质的可植入材料可以彻底改变术后护理.

研究的目的:

设计一种具有增强抗癌活性的植入物表面,以对抗OSCC.
研究改性表面抗癌作用的生物学机制.
评估这种修改后的植入物在局部化术后OSCC治疗中的潜力.

主要方法:

植入物被表面修饰,使用了合并的化和厌氧电沉积过程.
涂层 (Ti/Coating) 与未涂层 (Ti) 的生物效应在SCC-25 OSCC细胞上进行了评估.
分析了细胞亡,细胞循环,细胞内ROS,基因/蛋白质表达 (细胞亡,增殖,EMT,信号通路) 和细胞迁移.

主要成果:

/涂层系统显著降低了OSCC细胞活力和诱导的亡,并增加了ROS生成.
亡与BAX上调和BCL2下调,以及G2/M阶段的细胞循环停止有关.
/涂层抑制了表皮细胞-介质细胞转换 (EMT) 标记物,减少了迁移,并抑制了关键的瘤信号通路 (AKT/mTOR,Wnt/β-catenin).

结论:

开发的Ti/Coating系统通过诱导亡,氧化应激升高以及EMT和信号通路的调节,对口腔癌细胞表现出显著的抗癌作用.
这种生物活性植入物材料对OSCC的局部术后治疗具有前景.
表面修改将从抗癌惰性转化为抗癌活性,为植入物提供双重功能.

关键词:

基托桑是一种酸盐.涂层与细胞的相互作用纳米-氧亚帕提特是一种纳米-氧亚帕提特.口腔癌细胞是口腔癌的细胞.是一种.表面化学修饰表面化学修饰

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