患有炎症性肠道疾病的妇女使用避孕药:最新的系统性审查
Lauren B Zapata1, Emily M Snyder2, Naomi K Tepper1
1Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, United States; United States Public Health Service Commissioned Corps, Atlanta, GA, United States.
Contraception
|July 20, 2025
概括
在患有炎症性肠病 (IBD) 的女性中使用荷尔蒙避孕药显示出不一致的疾病活动风险. 证据仍然有限,没有明确与其他不良事件或激素水平变化的联系.
科学领域:
- 胃肠道学和生殖健康
背景情况:
- 患有炎症性肠病 (IBD) 的女性使用荷尔蒙避孕药可能会影响疾病活性和避孕药的有效性.
- 之前的系统审查强调了需要更新关于这个主题的证据.
研究的目的:
- 系统地审查和更新有关IBD妇女使用避孕药的安全性和有效性的证据.
- 评估这一群体中不良结果和避孕疗法的有效性风险.
主要方法:
- 在多个数据库中进行了全面的文献搜索,截至2024年7月15日.
- 包括专注于避孕和IBD的研究,评估疾病活动,复发,不良事件和口服避孕药 (OC) 的有效性等结果.
- 在包括的研究中,评估了偏差风险和证据确定性.
主要成果:
- 审查了15篇文章,包括8项新研究;大多数有偏见的高风险.
- 关于OC使用和IBD疾病活性或复发的证据不一致,一些研究显示关联增加或减少,通常不具有统计学意义.
- 在OC使用和静脉血栓塞栓症 (VTE) 或异常的宫涂抹之间没有发现显著的关联;药理动力学研究显示激素度没有差异.
结论:
- 有限的,低确定性证据表明,关于IBD女性荷尔蒙避孕的疾病活动或复发风险增加的不一致的发现.
- 在其他不良事件或避孕激素度方面没有观察到显著差异.
- 需要进一步进行高质量的研究,以解决有关VTE风险和IBD妇女避孕有效性的证据差距.
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