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Updated: Sep 14, 2025

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食纤维摄入量和前列腺癌结果和全因死亡率:前列腺,肺,结肠直肠和卵巢癌查研究的二次分析结果
Yanxu Yang1, Yuan Wang2, Hongke Wu3
1Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia.
Journal of the Academy of Nutrition and Dietetics
|July 20, 2025
概括
高食纤维摄入量与男性全因死亡率的降低有关. 虽然总和可溶性纤维可能会降低前列腺癌的风险,但需要进一步的研究来证实这些发现.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 前列腺癌是美国普遍存在的恶性瘤.
- 饮食纤维对癌症风险和死亡率的作用正在调查中.
- 食纤维对前列腺癌风险和死亡率的具体影响尚不清楚.
研究的目的:
- 研究饮食纤维摄入量与前列腺癌风险之间的关联.
- 检查饮食纤维摄入量与前列腺癌特定死亡率之间的关系.
- 评估饮食纤维摄入量与全因死亡率之间的关联.
主要方法:
- 前列腺癌,肺癌,结肠直肠癌和卵巢癌查研究 (PLCO) 的二次分析.
- 纳入了49476名55-74岁的参与者,来自两个研究部门:年度查和常规护理.
- 使用Cox比例危险和竞争风险回归来评估食纤维摄入与结果的关联的统计分析.
主要成果:
- 在年度查组中,高总纤维摄入量与降低前列腺癌风险有关 (aHR 0.87;95% CI,0.76至0.99).
- 在常规护理组中,高溶性纤维摄入量与降低前列腺癌风险有类似的关联 (aHR 0.86;95% CI,0.75至0.98).
- 在这两组研究中,观察到所有类型的食纤维摄入量 (总摄入量,不溶性,溶性) 和全因死亡率之间存在显著的反向关联 (P < .01). 对于晚期前列腺癌风险或前列腺癌特异性死亡率,没有发现显著的关联.
结论:
- 高食纤维摄入量 (总,可溶和不可溶) 与全因死亡率的降低有关.
- 食纤维可能具有保护作用,需要进一步研究.
- 建议进行前性研究,以验证这些发现并探索机制.
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