慢性口服亚酸盐使用与眼睛高血压和开放角度玻璃眼瘤风险之间的关联
Abdelrahman M Elhusseiny1, Taher K Eleiwa2, Rami Darwich3
1Department of Ophthalmology, Jones Eye Institute (A.E., M.C., Q.D.), University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA; Department of Ophthalmology, Boston Children's Hospital (A.E.), Harvard Medical School, Boston, Massachusetts, USA.
American journal of ophthalmology
|July 20, 2025
概括
在患有缺血性心脏病的患者中,口服酸盐的使用与患开角玻璃眼 (OAG) 和初级开角玻璃眼 (POAG) 的风险较低有关. 没有发现与眼睛高血压 (OHT) 有意义的关联.
科学领域:
- 眼科医生 眼科 眼科
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性缺血性心脏病 (IHD) 影响全球数以百万计的人.
- 玻璃眼和眼睛高血压 (OHT) 是不可逆转失明的主要原因.
- 了解药物的副作用和益处对于患者护理至关重要.
研究的目的:
- 调查口服酸盐使用与患眼高血压 (OHT) 和开角玻璃眼 (OAG) 的风险之间的关联.
- 评估诊断为慢性缺血性心脏病 (IHD) 的患者的长期风险.
主要方法:
- 使用TrinetX美国协作网络 (2005-2023) 的非身份化数据进行了回顾性队列研究.
- 患有慢性IHD的40岁以上的患者分为酸盐使用者 (≥4处方) 和非使用者.
- 倾向分数匹配 (PSM) 和考克斯比例危险模型被用于分析结果.
主要成果:
- 酸盐使用与3年和5年的OAG风险明显降低相关 (aHR分别为0.82和0.68).
- 在3年和5年观察到初级开角青光眼 (POAG) 的风险降低 (aHR分别为0.78和0.67).
- 酸盐使用和OHT发展之间没有发现显著的关联;酸盐使用者需要更少的玻璃眼治疗.
结论:
- 在IHD患者中,口服酸盐的使用与长期发展OAG和POAG的风险降低有关.
- 没有发现口服酸盐对OHT发展的影响.
- 研究结果表明,酸盐可能有保护作用,防止青光眼的进展.
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