气体传递剂在热致死中的作用
Hong-Jie Li1, Meng-Yuan Hao1, Hang-Shen Han1
1Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, School of Stomatology, Henan University, Kaifeng, Henan 475004, China; School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
International journal of biological macromolecules
|July 20, 2025
概括
像H2S,NO和CO这样的气体传递物在热中扮演着双重的角色,这是一个被编程的细胞死亡. 它们可以通过调节关键信号通路来抑制或促进热,为炎症性疾病和癌症提供治疗潜力.
科学领域:
- 细胞生物学 细胞生物学
- 细胞死亡的分子机制
- 炎症和疾病 炎症和疾病
背景情况:
- 烧死是一种被编程的细胞死亡途径,其特征是细胞胀和破裂,导致炎症.
- 炎症体触发热,使其分子机制对理解疾病至关重要.
- 气体传递物,包括硫化 (H2S),氧化 (NO) 和一氧化碳 (CO),都涉及到细胞过程.
研究的目的:
- 审查H2S,NO和CO在热的双重作用.
- 总结它们在瘤和炎症疾病中的作用机制.
- 突出在疾病治疗中准气体递质的治疗含义.
主要方法:
- 关于气体传递剂和热的研究的文献综述.
- 分析所涉及的分子通路,包括NF-κB/NLRP3,ROS和nrf2信号.
- 检查对关键的灭与相关的蛋白质 (例如,caspase-1,GSDMD) 和细胞因子 (例如,IL-1β) 的影响.
主要成果:
- H2S,NO和CO对热致死产生双重影响,能够同时抑制和促进.
- 抑制热致死包括抑制NF-κB/NLRP3通路,减少ROS,并激活nrf2信号传递.
- 通过增加NLRP3,ASC,caspase-1,GSDMD和IL-1β的表达,可以促进热致死.
结论:
- 气体递质通过复杂的分子机制显著影响热.
- 准气体传递体为炎症性疾病和癌症提供了潜在的治疗策略.
- 对气体传递剂供体药物和酶抑制剂的进一步研究对于临床应用是有必要的.
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