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一项关于血液中的和抑郁症状的纵向代谢学研究

Mingyu Feng¹, Wen Xu², Tonghai Zhao³

¹School of Public Health, Binzhou Medical University, No. 346 Guanhai Road, Laishan District, Yantai, Shandong, China.

Scientific reports

|July 20, 2025

概括

暴露于与年轻成年人,特别是男性的抑郁症得分较高有关. 这项研究揭示了的存在.

科学领域:

环境健康环境健康
神经科学是一个神经科学.
代谢学代谢学代谢学

背景情况:

暴露于是一种日益严重的公共卫生问题.
与神经健康,包括抑郁症之间的关联需要进一步调查.
了解影响的代谢途径对于识别毒性机制至关重要.

研究的目的:

研究中国年轻成年人血液中含量与抑郁症状之间的关联.
为了识别因暴露于而改变的代谢途径.
探索与抑郁关系中的潜在性别差异.

主要方法:

对477名中国本科生 (2019-2021) 的横截面研究.
使用患者健康问卷-9 (PHQ-9) 评估抑郁症状.
用ICP-MS测量血液中的,用LC-MS测量血清代谢量.
使用线性混合效应模型和ANOVA的统计分析.

主要成果:

血中的含量增加2倍与抑郁症得分增加0.50相关 (95%CI:0.14,0.86).
这种关联在男性中显著更强 (0.87增加,95%CI:0.12-1.61).
44种代谢物被改变,其中7种富含氨基酸代谢途径.
鱼类消费 (≥每月一次) 与含量有负相关性.

结论:

暴露于与年轻成年人的抑郁症状增加有关,男性的效果更为明显.
可能通过氨基酸代谢的改变影响抑郁症,可能影响神经递质,能量和炎症通路.
这些发现强调了监测暴露及其神经毒性影响的重要性.

关键词:

血液中的水银.中国的年轻人,中国的年轻人.群组研究是一项群组研究.抑郁症的症状抑郁症的症状代谢学代谢学代谢学

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