在双相情感障碍中表征个体内变异性:与认知,白质微观结构和临床变量之间的联系
Georgia F Caruana1, Sean P Carruthers2, James A Karantonis1,2
1Department of Psychiatry, https://ror.org/01ej9dk98The University of Melbourne, Melbourne, VIC, Australia.
Psychological medicine
|July 20, 2025
概括
在双相情感障碍 (BD) 患者中,个体内变异性 (IIV) 比健康个体高. 这种增加的IIV与较差的认知功能和BD中改变的白质微观结构相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 双极性障碍 (BD) 研究往往忽视了个体内变化 (IIV),而是专注于平均表现.
- 衡量人内一致性的IIV是一种独特的认知构造.
- 在BD中理解IIV对于识别独特的认知概况至关重要.
研究的目的:
- 为了调查反应时间的个体内变化 (IIV) 在双相情感障碍 (BD) 患者和健康对照 (HCs) 之间是否有差异.
- 检查IIV与各种领域的认知表现的关联.
- 在BD中探索IIV和白质微观结构之间的关系.
主要方法:
- 100名BD门诊患者和117名HC完成了认知任务,评估了处理速度,注意力,记忆和执行功能.
- 个人内变异性 (IIV) 被计算为连续性能测试相同对反应时间的标准偏差.
- 55名BD参与者进行了扩散张力成像,以评估白质的完整性.
主要成果:
- 与健康对照组 (HCs) 相比,双极性障碍 (BD) 参与者表现出明显更高的个体内变异性 (IIV).
- 在BD中IIV升高与多个认知任务中较低的平均绩效得分有关.
- 增加的IIV与减少的分数异质性和增加的全脑白质中的辐射扩散性相关.
结论:
- 个体内变化 (IIV) 是双相情感障碍 (BD) 的一个高度认知特征.
- 在BD中,IIV与更广泛的认知缺陷和白质异常有关,包括脱髓化.
- IIV为未来的双相情感障碍研究提供了一个潜在的有价值的神经生物学信息的措施.
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