在牙周炎中失调的非编码RNA表达的临床影响:从系统性审查和元分析中综合证据
Liping Fan1, Dan Wu2
1Department of Prosthodontics, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, No.758 Hefei Road, Qingdao City, 266035, Shandong Province, China.
Odontology
|July 20, 2025
概括
非编码RNAs (ncRNAs) 显示了牙周炎的良好诊断性能. 这些分子有效地区分健康个体和牙周炎患者,表明它们作为生物标志物的潜力.
科学领域:
- 生物分子科学 生物分子科学
- 口腔健康研究研究 口腔健康研究
- 诊断医学 诊断医学
背景情况:
- 非编码RNAs (ncRNAs) 在调节炎症反应和骨再吸收方面发挥着至关重要的作用.
- 牙周炎是一种复杂的炎症性疾病,影响牙的支结构.
研究的目的:
- 系统地审查和进行元分析,评估ncRNAs在牙周炎的诊断价值.
- 评估ncRNAs作为牙周炎生物标志物的敏感性,特异性和整体诊断准确性.
主要方法:
- 在PubMed,EMBASE和Web of Science数据库中的系统文献搜索.
- 对13篇精选文章的元分析,包括38个试验,820个对照和948个病例.
- 使用聚合的灵敏度,特异性,曲线下的面积 (AUC),概率比率和诊断几率比率 (DOR) 来评估诊断性能.
主要成果:
- 对于诊断牙周炎的ncRNAs,观察到0.79 (95% CI:0.73-0.84) 的聚合灵敏度和0.83 (95% CI:0.78-0.86) 的特异性.
- 曲线下的面积 (AUC) 为0.88 (95% CI:0.85-0.90),表明了良好的诊断性能.
- 诊断几率比 (DOR) 为17.75 (95% CI:12.12-26.00) 表明诊断的准确性显著.
结论:
- 失调的非编码RNA显示了牙周炎的显著诊断准确性.
- ncRNAs有潜力作为可靠的生物标志物来区分牙周炎和健康状况.
- 进一步的研究可能会探索这些发现的临床适用性.
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