生物标志物以指导败血症管理
Vasiliki Bourika1, Evangelia-Areti Rekoumi1, Evangelos J Giamarellos-Bourboulis2,3
1Hellenic Institute for the Study of Sepsis, Athens, Greece.
Annals of intensive care
|July 20, 2025
概括
生物标志物有助于早期的败血症诊断和指导治疗. 本综述强调了最近关于细菌或病毒性败血症生物标志物的发现,通过量身定制的管理策略改善了患者的治疗结果.
科学领域:
- 临界护理医学 临界护理医学
- 翻译医学是一种翻译医学.
- 生物标志物发现发现
背景情况:
- 败血症是导致死亡的主要原因,需要改进治疗策略.
- 精密治疗提供了一种有希望的方法来提高患者的治疗结果.
- 生物标志物对于识别特定的致病途径和指导向治疗至关重要.
研究的目的:
- 审查细菌和病毒性败血症生物标志物的最新进展.
- 探索生物标志物在指导及时诊断和个性化管理中的作用.
- 总结关于生物标志物的证据,以优化败血症治疗策略.
主要方法:
- 对与败血症管理相关的关键词进行了PubMed搜索.
- 分析了过去五年的相关生物标志物的证据.
- 专注于早期识别的生物标志物,抗生素的使用,流体治疗,血管压缩剂和免疫治疗.
主要成果:
- 肝素结合蛋白 (HBP),单细胞分布宽度 (MDW),中白素-10 (IL-10),前素,前素和C反应蛋白 (CRP) 已被确定用于早期败血症诊断.
- 甲素被强调为指导抗生素治疗的经过充分研究的生物标志物.
- 内皮细胞和心脏生物标志物显示出定制循环支持的潜力,包括液体治疗和血管压缩剂的使用.
结论:
- 生物标志物可以优化免疫调节疗法在败血症.
- 生物标志物指导对于启动血管抑制剂和告知抗生素管理是必不可少的.
- 生物标志物有助于流体复苏决策,最终改善患者的治疗结果.
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