在棚式环境中长大慢性地改变了后代的行为和生理学
Logan J Bigelow1, Emily K Pope1, Carey G Ousley1
1Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada.
The European journal of neuroscience
|July 21, 2025
概括
哺乳母婴和幼的环境丰富会影响长期的生理和行为结果. 标准化的养殖条件对于改善实验室动物福利和研究可重复性至关重要.
科学领域:
- 动物行为和动物福利.
- 发育神经科学的发展神经科学.
- 实验室动物科学实验室动物科学
背景情况:
- 动物的环境丰富性研究通常集中在青少年和成年人身上,对哺乳母和幼的数据有限.
- 之前的观察表明,养在架中的幼与单层子中的幼的行为和生理差异.
研究的目的:
- 为了研究长期影响的养动物幼在架子 (丰富) 和单层 (标准) 子.
- 评估养育环境对幼犬发育,压力生理学,行为和空间记忆的影响.
- 为了评估不同环境中的水中与压力相关的行为.
主要方法:
- 评估了幼的体重,超声波发声,头发皮质水平,开放场地和高加迷宫行为,以及空间工作记忆.
- 用开放场地和高层加迷宫测试来评估与压力相关的行为.
- 在丰富的 (架子) 和标准 (单层) 子中养的老鼠之间的比较.
主要成果:
- 在丰富子中养的成年老鼠体重较低,毛皮皮质度较高.
- 被丰富养殖的老鼠在升高的迷宫的开放臂膀中减少了探索,频率调节的超声波发声也减少了.
- 位于丰富中的水在开放场的中心时间较短,这表明压力反应发生了变化.
结论:
- 养殖条件显著影响动物的长期行为和生理特征.
- 早期发育过程中的环境丰富对压力反应和行为有持久的影响.
- 优化养殖条件对于提高实验室动物福利和提高研究结果的可复制性至关重要.
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