早餐时间减轻了肥胖的高多基因风险
R De la Peña-Armada1, María Rodríguez-Martín2,3, Hassan S Dashti4,5,6
1Department of Nutrition and Food Science, Complutense University of Madrid, Madrid, Spain.
Obesity (Silver Spring, Md.)
|July 21, 2025
概括
晚餐时间与较差的减肥维护有关. 对肥胖的遗传倾向可能会放大这种效应,突出了个性化体重管理策略.
科学领域:
- 营养科学 营养科学
- 遗传学 遗传学 是一个
- 肥胖问题研究研究
背景情况:
- 饮食时间是一个可修改的行为,可能会影响体重管理.
- 遗传因素对个体对肥胖的易感性起着重要作用.
- 了解行为与遗传学之间的相互作用对于有效的肥胖治疗至关重要.
研究的目的:
- 调查食物时间和长期减肥维持之间的关联.
- 检查饮食时间和遗传倾向 (PRS-BMI) 之间对体重结果的潜在相互作用.
- 探索食物时间与特定的BMI相关遗传变异的相互作用.
主要方法:
- 在ONTIME研究中分析了1195名超重或肥胖的成年人的数据.
- 开发BMI的多基因风险评分 (PRS-BMI) 来评估遗传肥胖风险.
- 线性回归模型用于评估饮食时间,PRS-BMI和减肥维护之间的关联和相互作用.
主要成果:
- 晚餐时间的每小时延迟与长期体重增加2.2%有关,这表明减肥维护能力较差.
- 发现饮食时间和PRS-BMI (p=0.008) 之间存在显著的相互作用.
- 与基因风险较低的人相比,高PRS-BMI的个体每小时延迟进食时间就会经历更大的BMI增加 (2kg/m2).
结论:
- 饮食时间是长期减肥维持的重要因素.
- 饮食时间对BMI的影响可能会在具有更高遗传倾向肥胖的个体中得到放大.
- 这些发现支持对肥胖管理的个性化方法的需求,同时考虑行为和遗传因素.
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