在Look AHEAD研究中,身体组成轨迹与认知表现的变化之间的关联
Morgana Mongraw-Chaffin1, Joni K Evans2, Heather M Shappell2
1Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Obesity (Silver Spring, Md.)
|July 21, 2025
概括
在减肥期间保持尾肌肉量 (ALM) 与更好的认知功能和减少认知衰退有关. 仅仅减肥可能不足以防止认知衰老.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 神经科学是一个神经科学.
背景情况:
- 2型糖尿病,超重和肥胖与认知能力下降的风险增加有关.
- 减肥干预措施对于管理2型糖尿病和肥胖是常见的.
- 体重减轻期间身体组成变化的对认知功能的影响需要进一步研究.
研究的目的:
- 为了检查身体组成变化 (总体脂肪和尾肌肉质量[ALM]) 与认知能力下降之间的纵向关联.
- 为了调查萨科佩尼亚和肥胖症在减肥干预后认知变化中的作用.
主要方法:
- 从Look AHEAD-MIND研究中分析了972名患有2型糖尿病和超重/肥胖症的参与者.
- 使用双能X射线吸收计 (DXA) 来识别总体脂肪和ALM的潜在轨迹.
- 采用混合线性回归模型,调整多个共变量,以评估身体组成轨迹和认知变化之间的关系.
主要成果:
- 总体脂肪和稳定的ALM的减少与更高的认知评分有显著的关联.
- 萨科佩尼亚在认知得分上显示出显著的差异,而肥胖却没有.
- 人口和社会经济因素部分减弱了观察到的关联.
结论:
- 维持ALM和身体功能的减肥策略可能会减轻认知能力下降.
- 干预措施应考虑个体对与衰老相关的身体组成变化的弹性,以防止不良的认知结果.
更多相关视频
06:48Author Spotlight: Advancements in 3D Optical Imaging for Comprehensive Body Composition Assessment in Modern Research
Published on: June 7, 2024
1.4K
07:01Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
Published on: September 20, 2020
4.9K
相关概念视频
Cognitive Development During Adulthood
288
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
288
Longitudinal Research
12.5K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.5K
Regression Toward the Mean
6.5K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.5K
Biological Influences on Intelligence
220
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
220
