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相关概念视频

LTR Retrotransposons03:08

LTR Retrotransposons

17.9K
LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
17.9K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

11.9K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.9K
Retroviruses02:33

Retroviruses

12.7K
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
12.7K
Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

16.1K
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
16.1K
DNA-only Transposons02:57

DNA-only Transposons

14.8K
DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
14.8K
Transposons01:24

Transposons

168
Transposons, or "jumping genes," are small mobile genetic elements (MGEs) that range from 700 to 40,000 base pairs in length. They are found in all organisms and can move within the same chromosome or transfer to different chromosomes. In some cases, transposons can also jump between different host DNA molecules, such as plasmids or viruses, contributing to genetic variability.Barbara McClintock first discovered these mobile genetic elements in the 1940s while studying maize genetics, and she...
168

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相关实验视频

Updated: Sep 14, 2025

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level
11:52

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level

Published on: April 23, 2016

8.5K

使用 LTR_Stream 解读 LTR 逆转移子和三种鸟物种之间的复杂相互作用.

Tun Xu1,2, Stephen J Bush1, Yizhuo Che1,2

  • 1School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China.

Genomics, proteomics & bioinformatics
|July 21, 2025
PubMed
概括

我们开发了LTR_Stream,用于精确对植物中长端重复逆转移子 (LTR-RTs) 进行聚类. 这种工具揭示了复杂的LTR-RT宿主基因组相互作用,以及它们在Papaver物种中的全聚化后的减少.

关键词:
爸爸永远是我们的父亲.横向转移是一种水平转移.在LTR-RT爆炸爆发.在LTR-RT集群中.类似于TAD的结构结构.

更多相关视频

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level
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RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level

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Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR
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Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR

Published on: July 27, 2019

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相关实验视频

Last Updated: Sep 14, 2025

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level
11:52

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level

Published on: April 23, 2016

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RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level
11:04

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level

Published on: May 19, 2019

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Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR
10:54

Detection of Retrotransposition Activity of Hot LINE-1s by Long-Distance Inverse PCR

Published on: July 27, 2019

8.7K

科学领域:

  • 基因组学就是基因组学.
  • 植物生物学 植物生物学
  • 分子进化分子进化

背景情况:

  • 长端重复逆转移体 (LTR-RTs) 在植物基因组中很丰富,了解它们与宿主DNA的相互作用至关重要.
  • 对LTR-RTs的高分辨率表征具有挑战性,特别是在非模型植物物种中.

研究的目的:

  • 开发一个新的计算工具,LTR_Stream,用于精确的LTR-RTs的子系群集.
  • 使用LTR_Stream. 调查LTR-RTs与Papaver物种宿主基因组之间的复杂相互作用.
  • 探索全聚化对LTR-RT活性和宿主基因组相互作用的影响.

主要方法:

  • 开发LTR_Stream用于高分辨率的LTR-RT子系谱集群.
  • 应用LTR_Stream来分析三种Papaver物种中的Retand LTR-RTs.
  • 对LTR-RTs及其基因组相互作用的比较分析. 化前和后.

主要成果:

  • 与基于数据库的方法相比,LTR_Stream在LTR-RT集群中提供了更高的精度.
  • 自主Retand元素在祖先亚基因组中传播,增强遗传多样性.
  • 包含转录因子动图 (例如,TCP,bZIP) 的截断的LTR-RT片段有助于创建新的拓学关联域类 (TAD类) 边界.
  • 在Papaver物种中的全聚化减少了观察到的LTR-RT效应,这表明了应对机制.

结论:

  • LTR_Stream是研究非模型植物物种中的LTR-RTs的一个有价值的工具.
  • LTR-RTs在塑造植物基因组进化,包括遗传多样性和基因组结构方面发挥着重要作用.
  • 聚化可以作为植物管理LTR-RTs影响的策略.