维生素D补充剂对主要心血管不良事件的影响:基于随机对照试验的元分析
Xiaoqing Cheng1, Zhenghao Chen2, Yingying Fang3
1Intensive Care Unit, Hospital of Zhejiang People's Armed Police (Hospital of Zhejiang PAP), Hangzhou, Zhejiang, People's Republic of China.
The British journal of nutrition
|July 21, 2025
概括
维生素D补充剂在一般人群中没有显著减少主要心血管不良事件 (MACE). 然而,它可能有助于降低心肌梗塞风险,特别是在超重或肥胖个体.
科学领域:
- 心血管健康 心血管健康
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 主要不良心血管事件 (MACE) 仍然是全球疾病和死亡的主要原因.
- 维生素D缺乏是常见的,并且已经研究了它在心血管健康中的潜在作用.
- 之前的研究对维生素D补充和心血管结果产生了相互矛盾的结果.
研究的目的:
- 进行一项元分析,评估维生素D补充剂与主要心血管不良事件 (MACE) 发生率之间的关系.
- 评估维生素D对特定心血管事件的影响,包括心肌梗塞,中风和心血管死亡.
- 探索潜在的调节因素,如体重指数 (BMI),对维生素D和MACE之间的关联.
主要方法:
- 在PubMed,科学网,奥维德,科克莱恩图书馆和临床试验的系统文献搜索到2024年7月.
- 包括五项随机对照试验 (RCT),报告了维生素D补充剂和MACE.
- 使用危险比率 (HR) 和95%置信区间 (CI) 的元分析来评估相关性.
主要成果:
- 聚合分析显示,维生素D和对照组之间的MACE发生率没有显著差异 (HR:0.96,P=0.77).
- 与维生素D (HR:0.88,P=0.061) 观察到心肌梗塞 (MI) 发病率较低的趋势,但在统计学上不显著.
- 补充维生素D并没有显著影响中风或心血管死亡的发生率. 在BMI≥25kg/m2 (HR:0.91,P=0.055) 的个体中,注意到MACE的潜在益处.
结论:
- 维生素D补充剂在一般人群中没有显著降低MACE,中风或心血管死亡的风险.
- 补充维生素D可能有助于降低心肌梗塞发病率.
- 体重指数影响维生素D对MACE的影响,这表明对超重/肥胖个体有潜在的益处.
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