评价孟曼丁对耳严重性的影响
Babak Pourayyoubi1, Alireza Rezaei-Ashtiani2, Javad Javaheri3
1Student Research Committee, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Brain and behavior
|July 21, 2025
概括
孟曼丁显著降低了患者耳的严重程度和不适. 这项研究表明,孟坦因是对耳有前途的治疗方法,改善了通过耳严重程度指数测量的结果.
科学领域:
- 神经学 神经学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 耳涉及在没有外部刺激的情况下感知声音,通常与NMDA受体过度活跃和兴奋毒性有关.
- 像孟坦丁这样的NMDA受体对抗剂显示出对耳治疗的潜力.
研究的目的:
- 评估孟坦丁在治疗耳的疗效.
- 进行双盲,随机,安慰剂对照的临床试验,使用美曼丁治疗耳.
主要方法:
- 70名耳患者被随机分为两组:干预 (记忆素+辛纳) 和安慰剂 (仅含辛纳).
- 两组人均每天两次服用肉素25毫克;干预组人均每天两次服用肉素25毫克;干预组人均每天两次服用肉素25毫克;干预组人均每天两次服用肉素25毫克;干预组人均每天两次服用肉素25毫克;干预组人均每天两次服用肉素25毫克;干预组人均每天两次服用肉素25毫克;干预组人均每天两次服用肉素25毫克;干预组人均每天两次服用肉素25毫克.
- 耳严重程度指数 (TSI) 和数值评分表 (NRS) 在治疗前和治疗后进行了评估.
主要成果:
- 两组之间NRS和STI分数没有显著的基线差异.
- 在治疗后,NRS和TSI分数在记忆剂干预组显著下降.
- 虽然NRS分数在两组中都有所改善,但只有TSI分数在干预组中显示出显著的下降.
结论:
- 孟曼丁在缓解耳症状和相关不适方面表现出显著的效果.
- 研究结果表明,孟坦因是治疗耳的潜在有效治疗剂.
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