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相关概念视频

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

193
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
193

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相关实验视频

Updated: Sep 14, 2025

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
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DOE优化的Minitabs:制造一个有前途的修改释放喷雾配方.

Suman R Borsadiya1, Dharmik M Mehta2

  • 1Department of Pharmaceutical Sciences, Faculty of Health Sciences, Marwadi University, Rajkot-Morbi Highway, Rajkot-360003, Gujarat, India.

Recent advances in drug delivery and formulation
|July 21, 2025
PubMed
概括

这项研究开发了针对食障碍患者的修饰释放迷你,创造了一种新的喷雾配方,以方便药物管理. 优化的配方可确保药物持续释放长达8小时.

关键词:
美国能源部.缺口症 (Dysphasia) 是一种表达性障碍.迷你电池是什么意思经过修改释放的释放方法软食品是一种软食品.喷雾器配方的使用方法

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科学领域:

  • 制药科学 制药科学
  • 药物输送系统 药物输送系统

背景情况:

  • 缺食症显著影响生活质量,特别是在老年和儿科患者中.
  • 喷配方为患有吞困难的患者提供了可行的给药途径.
  • 开发修改释放喷雾配方提出了重要的配方挑战.

研究的目的:

  • 为了配制改性释放的埃托里科克西布迷你药片,作为喷配方.
  • 为了应对创建修改释放喷剂量形式的挑战.

主要方法:

  • 迷你桶 (直径3.2毫米,重量约22毫克) 是用金属模具和穿孔系统手工制造的.
  • 一个3x2完整的因数设计优化了独立因子:HPMC K4M (X1) 和K100M (X2).
  • 优化的依赖因素包括硬度,易碎性和药物释放在2,4和8小时.

主要成果:

  • 优化的配方显示药物持续释放长达8小时.
  • 最终的药剂形式包括一个硬的凝囊,大约含有22个分片.
  • 这种喷配方是为在软食品上使用而设计的.

结论:

  • 开发的配方可以作为各种药物的修改释放喷配方的平台.
  • 使用这种优化配方方法,可以对不同的药物进行进一步的研究.