癌症中的多氨酸:机制,代谢点和治疗机会
1Department of Medical Biology, Faculty of Medicine, Kutahya Health Sciences University, Kutahya, Turkey.
Anti-cancer agents in medicinal chemistry
|July 21, 2025
概括
准聚胺代谢提供了有前途的癌症疗法. 抑制聚胺生物合成的组合策略与核酸合成或蛋白酶路径一起,显示出改善结果的协同潜力.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 聚胺代谢对癌细胞增殖至关重要,调节DNA复制,蛋白质合成和细胞周期进展.
- 聚胺生物合成中的关键酶,甲酸脱碳酶 (ODC) 和S-adenosylmethionine脱碳酶 (AdoMetDC),在癌症中经常受到失调.
- 多氨酸 (PA) 对瘤生长至关重要,使其代谢途径成为有吸引力的治疗点.
研究的目的:
- 审查聚氨酸在癌症发展和进展中的作用.
- 探索针对聚胺代谢和其他关键癌症信号通路的组合疗法.
- 突出聚胺向癌症治疗的挑战和未来方向.
主要方法:
- 用PubMed对癌症中的聚胺代谢进行文献综述.
- 通过UALCAN门户网站分析ODC和AdoMetDC表达数据.
- 药物和抑制剂信息来自PubChem,临床试验数据来自ClinicalTrials.gov.gov.
主要成果:
- 致癌途径 (MYC,Akt,mTOR) 在癌症中驱动异常的聚胺代谢.
- MYC上调调节ODC1,有助于聚胺调节失调.
- MTAP酶缺陷使癌细胞对核酸合成和蛋白酶抑制剂产生敏感性.
结论:
- 聚胺生物合成与核酸合成或蛋白酶路径的联合抑制显示出协同作用的抗癌效应.
- 多氨酸在促进瘤生长和铁细胞死亡方面的双重作用构成了治疗挑战.
- 开发强效的选择性抑制剂和理解上下文依赖的PA功能是有效的聚胺向疗法的关键.
相关概念视频
02:57Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
01:15Drugs that Stabilize Microtubules
2.1K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.1K
01:10Drugs that Destabilize Microtubules
2.0K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
2.0K
01:27Transducer Mechanism: Enzyme-Linked Receptors
2.8K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.8K
01:26Targets for Drug Action: Overview
7.5K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
7.5K
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K