Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Poly(Glycerol-Sulfur) as a Functional Sustainable Nanomaterial: Synthesized by Anionic Ring Opening Polymerization of Elemental Sulfur.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Heterojunction Gate-Empowered OPECT Aptasensing: A Valid Protocol for Realizing High Current Gain at Low Electron Donor Dependency.

Analytical chemistry·2026
Same author

Assembly-Line Biosynthesis in Living-Cell Emulsions via Tunable Supramolecular Surface Chemistry.

Nature communications·2026
Same author

Study on the Self-Assembly and Dual-Stimuli-Responsive Behavior of Multi-amphiphilic Polymeric Architectures.

Polymer science & technology (Washington, D.C.)·2026
Same author

Mn-Induced Support Stabilization and Ir Electronic Activation Enable Acid-Stable, Low-Loading IrO<sub>2</sub> Water Oxidation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Human herpesvirus 7 integrates into host telomeres via its telomeric repeat arrays.

PLoS pathogens·2026

相关实验视频

Updated: Jun 21, 2026

Simple and Robust in vivo and in vitro Approach for Studying Virus Assembly
09:47

Simple and Robust in vivo and in vitro Approach for Studying Virus Assembly

Published on: March 1, 2012

12.4K

基于聚硫酸盐的生物活性纳米组件,用于对抗病毒感染.

Guoxin Ma1, Mathias Dimde2, Kai Ludwig2

  • 1Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.

Small (Weinheim an der Bergstrasse, Germany)
|July 21, 2025
PubMed
概括

具有多硫酸盐的新型3D纳米系统有效抑制像HSV-1和Omicron这样的病毒. 这些灵活的纳米粒子阻断病毒进入宿主细胞,显示出抗病毒应用的显著治疗潜力.

关键词:
抗病毒纳米组件 抗病毒纳米组件多价纳米系统多价纳米系统.聚硫酸盐的多硫酸盐.病毒抑制 病毒抑制

更多相关视频

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

8.0K
Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
07:33

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

1.9K

相关实验视频

Last Updated: Jun 21, 2026

Simple and Robust in vivo and in vitro Approach for Studying Virus Assembly
09:47

Simple and Robust in vivo and in vitro Approach for Studying Virus Assembly

Published on: March 1, 2012

12.4K
Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

8.0K
Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
07:33

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

1.9K

科学领域:

  • 纳米技术 纳米技术
  • 病毒学 病毒学
  • 生物材料科学 生物材料科学

背景情况:

  • 聚硫酸纳米系统通过动态变形和粘附于病毒,表现出强大的抗病毒特性.
  • 开发新的超分子纳米结构对于提高抗病毒疗效至关重要.

研究的目的:

  • 介绍一种由块共聚合物组装的新型超分子纳米系统,用于增强病毒抑制.
  • 评估纳米系统上不同硫化水平的抗病毒功效,以对抗简单疹病毒1型 (HSV-1) 和Omicron变种.

主要方法:

  • 将一个块共聚合物组装成100纳米球体,并具有类似刷子的冠状.
  • 测试HSV-1抑制的斑块减少试验中不同的硫化水平 (45%,76%,100%).
  • 电子显微镜 (cryo-EM) 用于可视化病毒与纳米系统的相互作用.
  • 在感染后模型和对Omicron变异的评估.

主要成果:

  • 由于外硫酸盐分布,纳米系统表现出异常的颗粒均性,增强了多价值相互作用.
  • 获得了HSV-1的非常低的半最大抑制度 (IC50) 值:分别为45%,76%和100%的硫酸组件的0.43,0.16和0.037μg/ml.
  • 化电磁波证实了纳米系统的多层捕获病毒.
  • 76%和100%的硫酸组件在感染后模型和对Omicron的治疗潜力.

结论:

  • 3D灵活的纳米组件有效地阻止病毒进入宿主细胞.
  • 优越的形态和高效率使这些硫酸纳米系统成为广泛的抗病毒应用的有希望的候选人.