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Updated: Sep 14, 2025

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

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Published on: July 21, 2018

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转录基因分析显示,通过ROS介导的JNK/NLRP3通路的激活,crizotinib诱导的肝毒性

Min Li1,2, Zhouli Yue2,3, Menglin Wang2,3

  • 1Department of Oncology, People's Hospital of Zhengzhou (People's Hospital of Henan University of Chinese Medicine), Zhengzhou, China.

Toxicology mechanisms and methods
|July 21, 2025
PubMed
概括

在小鼠中,crizotinib通过增加氧化应激和激活JNK/NLRP3通路而导致肝损伤,导致炎症和亡. 了解这些机制对于管理非小细胞肺癌治疗副作用至关重要.

关键词:
克里佐丁尼布 (crizotinib) 是一种可以灭症 (apoptosis) 是一种死亡的过程.肝毒性 肝毒性 肝毒性炎症反应是一种炎症反应.氧化应激是一种氧化应激.

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